Immunoprotection by polyethylene glycol in organ preservation solutions is not due to an immunomasking effect

Immunoprotection by polyethylene glycol in organ preservation solutions is not due to an immunomasking effect.

BACKGROUND New organ preservation solutions that contain soluble polyethylene glycol (sPEG) molecules have been associated with reduction of acute rejection episodes. METHODS In the present manuscript we tested in vitro whether sPEG molecules were able to mask donor alloantigens and reduce graft immunogenicity. RESULTS Immunomasking effect was only evidenced when PEG molecules were covalent...

Bowel preparation in children: is polyethylene glycol an answer?

of dose and duration of PEG preparations that will be useful for C olonoscopy is an important diagnostic and therapeutic procedure to evaluate the colon and terminal ileum in children. Anadequatebowelpreparationisnecessaryforcompletevisualization ofboththecolonandterminal ileum.Inadequatebowelpreparationcan lead topoorcolonicvisualization,missed lesions, increasedprocedure time, and possibly a ...

Bacterial survival in suspension in polyethylene glycol solutions.

Protective Effect of Intravenous High Molecular Weight Polyethylene Glycol on Fatty Liver Preservation

Ischemia reperfusion injury (IRI) leads to significant tissue damage in liver surgery. Polyethylene glycols (PEGs) are water soluble nontoxic polymers that have proved their effectiveness against IRI. The objective of our study was to investigate the potential protective effects of intravenous administration of a high molecular weight PEG of 35 kDa (PEG 35) in steatotic livers subjected to cold...

Foreign Body Response to Intracortical Microelectrodes Is Not Altered with Dip-Coating of Polyethylene Glycol (PEG)

Poly(ethylene glycol) (PEG) is a frequently used polymer for neural implants due to its biocompatible property. As a follow-up to our recent study that used PEG for stiffening flexible neural probes, we have evaluated the biological implications of using devices dip-coated with PEG for chronic neural implants. Mice (wild-type and CX3CR1-GFP) received bilateral implants within the sensorimotor c...